• WELCOME to KNOW
    The Knowledge in Naturopathic Oncology Website.

    KNOW is a dynamic clinical and educational tool that combines detailed summaries of up-to-date- research in integrative oncology with current best practices from experienced naturopathic physicians.

    KNOW is designed to help you quickly access pertinent information to make evidence-informed decisions.

  • KNOW Database 101

  • Here's what we did:

    • We asked the question "What is the role of integrative therapies in the clinical management of people with cancer?"
    • We searched across international databases to harvest published data pertaining to integrative oncology with a specific focus on nutraceuticals and diet. Initially we started with 4 search topics: Breast cancers, Thoracic cancers, Neuropathy and Curcumin and included data up until 2018.
    • We screened the data and acquired the selected articles.
    • We summarized all relevant (English language, human level of evidence) data using a PICO summary template (population, intervention, comparator, outcome) to provide an objective and detailed report.
    • We peer-reviewed and tagged all summaries so they are searchable.
    • We peer-reviewed and organized support literature &clinical pearls donated by experienced ND's in North America to be searchable by topics and type of document.
    • Beginning in 2017, we opened our search to include terminology for all tumor types, cancer-related conditions and natural treatments.
    • KNOW is working to summarize the relevant literature pertaining to integrative oncology for all tumor types, and cancer-related or cancer treatment related side-effects for 2010-2018.

    Here's why:

    • To provide clinicians and students in naturopathic oncology access to data for best education, safety & clinical decision-making
    • To allow colleagues to collaborate on research and publication projects

    Our goals:

    • Summarize the literature pertaining to integrative oncology for all tumor types, side effects and natural agents
    • Improve knowledge of integrative oncology research by clinicians
    • Support evidence informed patient care
    • Inspire collaboration

    • Here's what you get:

      1. Efficiency: Currently, enormous energy is spent with FABNOs and NDs entering the field trying to reinvent the same wheel to find and distill current literature.
      2. Staying up-to-date: The volume of research in integrative oncology is ever increasing and nearly impossible to stay abreast of; the KNOW team of researchers and medical librarians will keep the website current and can access full text articles and international studies that the average clinician cannot easily get.
      3. Communicating with conventional providers: Relationships with conventional oncology providers improves when integrative clinicians share evidence in their communications; KNOW research summaries and references can be copied/pasted into your documents.
      4. Evidence-informed practice: Making evidence- informed decisions requires easy access to relevant research and the clinical experience of our elders. KNOW puts this at your fingertips.
      5. Knowledge base for teaching: A central repository of information supports curriculum for naturopathic oncology residencies and ABNO exam content.
      6. Collaboration for publication projects: KNOW assembles the data so groups can help add to the literature reporting on natural agents in oncology care. Shared work in KNOW is eligible for continuing education credits.
      7. Growing competency and safety: We are building a comprehensive section in KNOW on "Interactions with Conventional Treatments."

  • KNOW is dedicated to all people who have experienced cancer, and with gratitude for those who volunteered in research to make this knowledge available to us.

Phone & Fax:1-800-908-5175
Email: oncanp@gmail.com

The content on the KNOW website is not intended nor recommended as a substitute for medical advice, diagnosis, or treatment.
Always seek the advice of your own physician or other qualified health care professional regarding any medical questions or conditions.
The use of this website is governed by the KNOW Terms of Use

©2019 KNOW, Inc.

KNOW

Knowledge in Naturopathic Oncology Website
Terms of Use
The Oncology Association of Naturopathic Physicians ("OncANP" or "we") provides the content posted on the KNOWoncology.org website and other related websites (the "KNOW Website") to you subject to the following Terms of Use. When you use the KNOW Website, you agree to be bound by these Terms of Use. These Terms of Use incorporate the KNOW Privacy Policy posted on the KNOW Website, as well as the terms of any subscriber agreement that may exist between you and KNOW. To the extent there is a conflict between these Terms of Use and your subscriber agreement, the terms of your subscriber agreement will control your use of the KNOW Website. Please read these Terms of Use carefully. If you do not agree with these Terms of Use, please do not use the KNOW Website.

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The KNOW Website, including the text, graphics, audio files and software that appear on the KNOW Website, is owned by or licensed to OncANP, and is subject to copyright and other intellectual property rights under United States, foreign laws and international conventions. Users may not re-post KNOW's content on other web sites without the permission of the OncANP. Users cannot re-sell KNOW's content to third parties, or prepare derivative works of KNOW's content.

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The KNOW Website is designed to offer users general health information for educational purposes only. The general health information furnished on this site is not intended to replace personal consultation with a qualified health care professional. You must always seek the advice of a professional for questions related to your health, disease, disease symptoms, and appropriate therapeutic treatments. If you have or suspect that you have a medical problem or condition, please contact a qualified health care professional immediately. You should never disregard medical advice or delay in seeking it because of something you have read on this site. IF YOU HAVE AN EMERGENCY, CALL 9-1-1. KNOW does not give medical advice, nor do we provide medical or diagnostic services. Neither KNOW nor any KNOW entity guarantees that the content covers all possible uses, direction, precautions, drug interactions, or adverse effects that may be associated with any therapeutic treatments. You may not rely on the application of any information on the KNOW Website as being applicable to your specific circumstances. Neither KNOW nor any KNOW Entity assumes any liability or responsibility for damages or injury to you, other persons, or property arising from any use of any information, idea, or instruction contained in the KNOW Website.

Permission to reproduce KNOW material
Patient Handouts may be re-printed and shared. All other materials on KNOW are intended for personal use only. To use any materials other than Patient Handouts, you must receive permission to reproduce from KNOW in writing.

To request permission to reproduce KNOW material please submit your request in writing via e-mail, fax, or regular mail. You may wish to include a copy of the material for which you are requesting permission. Your permission request must include the following information:
· Title of the topic review or figure (figure titles can be found in the outline of each topic review)
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· a statement by you, made under penalty of perjury, that the above information in your Notice is accurate and that you are the copyright owner or are authorized to act on the copyright owner's behalf

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KNOW

Knowledge in Naturopathic Oncology Website

Founding Sponsors

  • Oncology Association of Naturopathic Physicians (OncANP.org)
  • Ottawa Integrative Cancer Centre (oicc.ca)

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KNOW

Knowledge in Naturopathic Oncology Website

KNOW

Knowledge in Naturopathic Oncology Website


KNOW

Knowledge in Naturopathic Oncology Website

Website made possible by:

  • Oncology Association of Naturopathic Physicians (OncANP.org)
  • Ottawa Integrative Cancer Centre (oicc.ca)

KNOW Senior Research Associates:

  • Sarah Soles, ND
  • Sonam Desai, ND
  • Teresa Martin, MSc
  • Thanasi Psihogios (CCNM ND Candidate '19)

KNOW Research Associates:

  • Jennifer Tang (CCNM ND Candidate '21)
  • Deepa Bhatia (UofT PharmD Candidate)

Research Directors:

  • Jen Green ND FABNO
  • Heather Wright ND FABNO
  • Casey Martell, ND, FABNO, MBA

KNOW Information Specialists & Medical Librarians:

  • Becky Skidmore BA(H), MLS
  • Emily Gallaher MLS

Web Development & Design:

  • Caitlin Anstee

Special thanks to:

  • Karolyn Gazella
  • Naturopathic Oncology Foundation
  • The Natural Medicine Journal
  • OncANP Board of Directors
  • Canadian College of Naturopathic Medicine
  • University of Toronto
  • Corey Murphy, OncANP Exec. Director

Volunteers:

  • Sukriti Bhardwaj
  • Hayhlee Clarence
  • Kristina Fischer
  • Jennifer Havens, ND
  • Sheldon Jordan, ND
  • Marisa Soski
  • Alanna Welsh
  • Lin Dan Zhu

KNOW Advisory Board Members:



Methods by Topic

  • Tag Guideline for Systematic Review & Meta Analysis Articles


    1.0 Document Title

    1.1 Publication Year

    2.0 Brief summary
    (please include total number of human studies analyzed, overall conclusions, be brief)

    2.1 Study design type
    select drop down options:

    Systematic review
    Meta-analysis
    Systematic review and Meta-analysis

    2.2 Total number of human studies and type of studies included in the review
    (specify number of randomized controlled trials, controlled trials, uncontrolled trials, observational studies, case reports)
    ex. 7 Randomized controlled trials, 3 Controlled trials, 2 Uncontrolled trials

    2.3 Total number of non-human studies
    (options: None, # in vivo, #vitro, #ex vivo etc.)
    ex. 11 Vitro studies, 5 Vivo studies

    2.4. Criteria for Inclusion in methodology
    (separate criteria by comma)

    2.5 Search dates (separate dates or month/year time frames by comma)
    ex. 8/11/14 - 9/5/15, August 2013-June 2016, September 2011- October 2012

    3.0 Population described
    [Include number of participants total, cancer type (frequency breakdown of different types if available), cancer treatment type (adjuvant treatment e.g. surgery, radiation, chemotherapy, after care, advanced treatment, palliative care, hospice)]

    3.1 Number of participants
    (total analyzed in all human studies) ex. N= 40365

    4.0 Intervention Category
    Options: Supplemental, Dietary, Injectible, Topical, Physical, Mental/emotional [multiple selections ok]
    ex. Supplemental (includes oral capsules or tablets of anything, herbs of any kind such as tea or liquid extractions, minerals, vitamins, anything that is not part of a diet/meal, for shakes use both “supplemental” and “dietary” categories)
    Dietary (includes low fat diet, Mediterranean diet, fasting, ketogenic diet, can also include diet as a category if the intervention replaces food ie. shake or supplement instead of a meal or added to a meal)
    Injectable (this includes intravenous therapies, subcutaneous and intramuscular)
    Topical
    Physical (use this category only if combined with another intervention that is supplemental, dietary, injectable or topical. Do not use this category alone. If you find an article that has only a physical intervention such as exercise please notify Anne T.)
    Mental/emotional (note: use this category only if combined with another intervention that is supplemental, dietary, injectable or topical.

    4.1 Intervention described
    [Please include all reported by the study: agent or therapy name, descriptive characteristics, routes of application, dose range, duration of treatment. For intervention studies, include intervention, dose, timing. For observational studies, report the association between X and Y in population Z. note: this may vary in different groups of studies analyzed.] Describe each group separately if distinct groups are reported on in the analysis ie. different dosage levels, different durations of therapy or different routes of administration. If all are combined within the same analysis, ok to describe inclusively.

    4.2 Intervention name
    [Report the most descriptive &specific name of intervention provided by the study (eg. guarana, withania, or N/A if observational); report general name given in the study including acronyms if given; use the term “formula” for capsules, teas or powders with multi ingredients; if the study reports using a “multivitamin” use that as the intervention name; report different supportlit given in one study separated by a comma; do not worry about too many details here; the “intervention described” tag as well as “intervention ingredients” tags will cover this in more detail. For this section brevity is best.

    6.0 Outcome/Combined statistical results
    (Summarize outcomes; include direction of outcome with associated statistics; enter a different line for each outcome reported; attempt to prioritize primary outcome by listing first)

    6.1 Outcome Type
    Choose all that apply: (multiple options for selection ok)
    Function
    Adverse event
    Pain
    Clinical
    Side effect
    Wellbeing
    Safety
    Surrogate
    Feasibility
    Symptom
    Survival
    Quality of life
    Recurrence

    6.2 Outcome Results
    Options:
    Positive
    Negative
    Neutral (note: Neutral = no effect beyond placebo)
    Mixed

    7.0 Adverse events associated with intervention
    Options:
    None reported, Absent, or Present (followed by side effects eg. symptoms attributed to the intervention separated by commas) Note: does not refer to side effects of standard cancer treatment unless side effects result from the combination natural intervention + standard treatment and are attributed to either the combination or the natural agent alone as reported by study authors.

    7.1 Adverse events associated with intervention described
    Described if directly attributed to the intervention in the study by the study authors; if none reported by study write N/A.

    8.0 Interactions (Interactions with conventional treatments such as surgery, chemotherapy or radiation):
    Options/select one:
    Not reported
    Absent
    Reported and possible [use this option for non statistically significant]
    Present- beneficial
    Present – harmful

    8.1 Interactions Described
    If no interaction reported in the study, enter N/A; please report interactions as any favorable or unfavorable outcome related to use of the intervention by the study authors including side effects, adverse events, and primary/secondary objective outcomes.

    9.0 Tumor Type Tags
    These tags determine where the article is placed within the database, so please include all relevant tags. Ok to select multiple options if the study specifically discusses that topic. Select if the article presents information relevant to that topic AND the study authors discuss it.

    Brain &CNS (Astrocytoma, Glioma, Glioblastoma, Neuroblastoma, Medulloblastoma)
    Breast
    Cervical
    Colorectal
    Esophageal
    Head &Neck (Lip, Oral, Salivary gland, Laryngeal, Naso-pharyngeal)
    Kidney and Bladder (Wilms, Renal Cell, Bladder, Urethral)
    Leukemia &Lymphoma (ALL, AML, CLL, CML, Non-hodgkin lymphoma, Hogskin lymphoma, Hairy cell leukemia)
    Liver &GB (bile duct, hepatocellular)
    Lung (SCC, NSCC)
    Melanoma &Skin (Basal Cell, Squamous cell non-melanoma, T cell lymphoma)
    Myelodysplastic Syndromes &Multiple Myeloma
    Sarcomas (osteo, Rhabdo, soft tissue, Ewing, Uterine (see uterine), Kaposi)
    Ovarian
    Pancreatic
    Prostate
    Thyroid
    Uterine (sarcoma &endometrial)
    Vulvar
    Other Endocrine (parathyroid, pituitary, testicular, thymoma)
    Cancer Unknown Primary
    Other

    10.0 Side Effect Tags
    These tags determine where the article is placed within the database, so please include any relevant tags. Ok to select multiple options if the study specifically discusses that topic. Select if the article presents information relevant to that topic AND the study authors discuss it.

    Anorexia (loss of appetite)
    Anxiety (fear, worry)
    Bone marrow suppression (Neutropenia, thrombocytopenia, anemia, cytopenia, pancytopenia)
    Bone pain
    Bruising &Swelling
    Cachexia (sarcopenia, weight loss, anorexia)
    Cardiotoxicity (cardiomyopathy, ejection fraction, heart function)
    Cerebral edema
    Cognitive changes (chemotherapy brain, poor cognition)
    Constipation
    Cystitis (urinary tract infection, bladder infection)
    Depression
    Dermatitis (rash, skin pain)
    Diarrhea
    Erectile dysfunction
    Esophagitis
    Fatigue (Chemotherapy induced and radiation induced fatigue, lethargy, low energy, asthenia, ECOG)
    GERD (gastroesophageal reflux, reflux)
    Hand Foot Syndrome (PPE, Palmar Plantar Erythrodysethesia)
    Hematuria (blood in urine)
    Hot flushes (vasomotor symptoms, night sweats
    Insomnia (sleeplessness, somnolence)
    Joint pain
    Libido
    Lymphedema
    Mucositis (stomatitis, mouth sores)
    Myalgia
    Nausea and Vomitting
    Nephrotoxicity (kidney inflammation,nephropathy)
    Nocturia (night urination)
    Obesity (syndrome x, metabolic syndrome, overweight)
    Ototoxicity (hearing loss, tinnitus, vertigo)
    Osteoporosis
    Pericardial effusion
    Peripheral Neuropathy (Neuropathy, Radiation induced neuropathy, Chemotherapy Induced Neuropathy, Nerve, CIPN, Surgery induced Neuropathy)
    Peritoneal effusion
    Pleural effusion
    Radiation induced proctitis
    Scar tissue
    Subcapsular pain
    Vaginal dryness
    Wound repair
    Other
  • Breast Methodology


    BREAST RESEARCH QUESTION:
    What is the role of integrative therapies in the clinical management of breast cancer and survivorship?

    INCLUSION CRITERIA
    • English language article
    • Human
    • All tumor types/neoplastic cases [minimum of 25% study population with cancer]
    • KNOW beta topic -- contains data for all years
    • All outcomes including: Overall Survival (OS), Progression Free Survival (PFS), Quality of Life (QoL), and side effect management.
    • Females and males
    • All nutraceuticals (including oral supplements, dietary, intravenous, injectable, topical)
    • Diet therapy (Mediterranean, ornish, ketogenic, vegetarian, etc.)
    • Secondary prevention (articles that report data to prevent cancer from recurring)
    • Systematic Review articles and meta analyses with human data
    • Clinical guidelines

    EXCLUSION CRITERIA
    • Non- English language article
    • Non- human (eg. in vitro or in vivo non-human animal)
    • Non-neoplasms
    • Non-nutraceuticals/Non-diet CAM therapies (yoga, acupuncture, massage, etc.)
    • Primary prevention (articles that report data to prevent cancer from occurring)
    • Drug only trials (no metformin, LDN, DCA, IPT, light therapy, metronomic chemo)
    • Mind Body supportlit
    • Exercise only supportlit (no supplement, dietary, intravenous or topical therapies)
    • Prevalence/usage of CAM
    • Conference proceedings, trial postings without results; interim analyses

    KNOW SEARCH METHODOLOGY – INTEGRATIVE TREATMENTS IN BREAST CANCER

    Using the dietary supplement subset available in both PubMed and MEDLINE as our base, we created a line-by-line version of this filter for use in Embase. With the help of naturopathic doctors on the team, we identified additional relevant vocabulary that we incorporated into the filter. This filter was then paired with the pertinent vocabulary for breast cancer.

    We ran searches in Ovid MEDLINE, Ovid MEDLINE In-Process & Other Non-Indexed Citations and Embase Classic+Embase on May 31, 2015. Strategies utilized a combination of controlled vocabulary (e.g., Breast Cancer, Diet Supplementation, Omega 3 Fatty Acid) and keywords (e.g., breast cancer, nutraceutical, fish oil). Vocabulary and syntax were adjusted across the databases. No language or date restrictions were applied but animal-only and opinion-pieces were removed from the results.

    The search will be updated on a scheduled basis and relevant citations appraised for inclusion in KNOW.
  • KNOW Methodology – All topics


    RESEARCH QUESTION:
    What is the role of integrative therapies in the clinical management of cancer patients and survivors?

    INCLUSION CRITERIA:
    English language
    Articles published in the years 2010-2017
    Human experimental studies including meta-analyses, systematic reviews, clinical trials, observational data, case reports (population must include humans with cancer or survivors)
    Population includes humans with cancer (all tumor types) and survivors of cancer (ie. diagnosed with cancer and forward in time)
    All outcomes including: Overall Survival (OS), Progression Free Survival (PFS), Recurrence, Quality of Life (QoL), side effect management, Patient reported outcomes (PROs), and Clinical guidelines
    Females and males
    All nutraceuticals (including oral supplements, botanicals, homeopathy, dietary, intravenous, injectable, topical, natural agent complexed to pharmaceutical)
    Diet therapy (Mediterranean, Ornish, Vegetarian, etc.)
    If combined with nutraceutical in study: Mind body, Exercise therapy, Yoga therapy, Prayer, Hypnotherapy, Light therapy, Hydrotherapy, Acupuncture and oriental medicine

    EXCLUSION CRITERIA:
    Non-English language
    Non-human experimental (eg. in vitro or in vivo non-human animal)
    Studies that do not include cancer population or survivors
    Any condition NOT resulting from cancer or treatment of cancer
    Drug only trials (no metformin, LDN, DCA, IPT, metronomic chemo etc. unless natural agents are studied in the context of the design)
    Prevalence/usage of CAM
    Conference proceedings
    Trial postings without results; interim analyses

    NOTE: At this time we are working to only summarize data for secondary prevention ie. Studies conducted on patients after diagnosis with cancer and survivors and we are NOT summarizing studies on the primary prevention of cancer.

    KNOW – All topics
    Using the dietary supplement subset available in both PubMed https://www.nlm.nih.gov/bsd/pubmed_subsets/diet_strategy.html and MEDLINE as our base, we created a line-by-line version of this filter for use in Embase. With the help of naturopathic doctors on the team, we identified additional relevant vocabulary that we incorporated into the filter. This filter was then paired with the pertinent vocabulary for all cancers.

    We ran the searches in Ovid MEDLINE®, Ovid MEDLINE® In-Process & Other Non-Indexed Citations and Embase on April 6, 2016. Strategies utilized a combination of controlled vocabulary (e.g., Neoplasms, Flavonoids, Homeopathy) and keywords (e.g., cancer, glutamine, probiotic). Vocabulary and syntax were adjusted across the databases. There were no language limits but the initial searches were restricted to the publication dates 2013 to the present and animal-only and opinion-pieces were removed from the results. We ran these same strategies during the dates September 24 to 29 to include the publication dates 2010 to 2012 and also to include the newly added OVID MEDLINE database Epub Ahead of Print. On January 1, 2017, we re-ran the searches to incorporate results for all of 2016.

    The search will be updated on a scheduled basis (e.g., annually) and relevant citations incorporated.

    Specific details regarding the strategies appear in Appendix 1.
  • Neuropathy Methodology


    NEUROPATHY RESEARCH QUESTION:
    What is the role of integrative therapies in the clinical management of cancer treatment related peripheral neuropathy in cancer patients and survivors?

    INCLUSION CRITERIA
    • English language
    • Human experimental
    • All cancer tumor types and survivors with neuropathy related to the treatment of cancer (ie. by surgery, chemotherapy, or radiation)
    • KNOW beta topic -- contains data for all years
    • All outcomes including: Overall Survival (OS), Progression Free Survival (PFS), Recurrence, Quality of Life (QoL), and side effect management
    • Females and males
    • All nutraceuticals (including oral supplements, botanicals, homeopathy, dietary, intravenous, injectable, topical), Diet therapy (Mediterranean, ornish, vegetarian, etc.), Acupuncture and oriental medicine, Mind body supportlit, Exercise therapy, Yoga therapy, Prayer, Hypnotherapy, Light therapy, Hydrotherapy. (Natural agent complexed to pharma ok.)
    • Systematic Review articles and meta analyses with human data
    • Clinical guidelines

    EXCLUSION CRITERIA
    • Non- English language article
    • Non- human (eg. in vitro or in vivo non-human animal)
    • Non-cancer or non-cancer treatment related neuropathy (ie. diabetic)
    • Any neuropathy type NOT resulting from cancer or treatment of cancer
    • Drug only trials (no metformin, LDN, DCA, IPT, metronomic chemo etc.)
    • Prevalence/usage of CAM
    • Conference proceedings
    • Trial postings without results; interim analyses

    NOTE: A word about primary prevention studies. While our search and criteria do include primary prevention studies, at this time we are working to only summarize data for secondary prevention ie. Studies conducted on patients after diagnosis with cancer and survivors and we are NOT summarizing studies on the prevention of cancer from occurring.

    KNOW SEARCH METHODOLOGY – INTEGRATIVE TREATMENT OF CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY

    Using the dietary supplement subset available in both PubMed and MEDLINE as our base, we created a line-by-line version of this filter for use in Embase. With the help of naturopathic doctors on the team, we identified additional relevant vocabulary that we incorporated into the filter. This filter was then paired with the pertinent vocabulary for chemotherapy-induced peripheral neuropathy.

    We ran searches in Ovid MEDLINE®, Ovid MEDLINE® In-Process ∓ Other Non-Indexed Citations and Embase Classic+Embase on October 15 and 17, 2015. Strategies utilized a combination of controlled vocabulary (e.g., Neoplasms, Peripheral Nervous System Disease, Platinum Compounds) and keywords (e.g., cancer, CIPN, cisplatin). Vocabulary and syntax were adjusted across the databases. No language or date restrictions were applied but animal-only and opinion-pieces were removed from the results.

    The search will be updated on a scheduled basis and relevant citations incorporated.
  • Thoracic Methodology


    THORACIC CANCERS RESEARCH QUESTION:
    What is the role of integrative therapies in the clinical management of thoracic cancer and survivorship?

    INCLUSION CRITERIA
    • English language article
    • Human
    • All thoracic cancer tumor types/neoplastic cases: lung, gastric and/or esophageal or pre-dominant focus of trial (minimum 25% thoracic cancer cases)
    • KNOW beta topic -- contains data for all years
    • All outcomes including: Overall Survival (OS), Progression Free Survival (PFS), Quality of Life (QoL), and side effect management.
    • Females and males
    • All nutraceuticals (including oral supplements, dietary, intravenous, injectable, topical)
    • Diet therapy (Mediterranean, ornish, ketogenic, vegetarian, etc.)
    • Physical therapies (yoga, exercise, acupuncture, massage)
    • Mental emotional therapies
    • Secondary prevention (articles that report data to prevent cancer from recurring)
    • Systematic Review articles and meta analyses with human data

    EXCLUSION CRITERIA
    • Clinical guidelines
    • Non- English language article
    • Non- human (eg. in vitro or in vivo non-human animal)
    • Non-neoplasms
    • Primary prevention (articles that report data to prevent cancer from occurring)
    • Drug only trials (no metformin, LDN, DCA, IPT, light therapy, metronomic chemo)
    • Prevalence/usage of CAM
    • Conference proceedings, trial postings without results; interim analyses


    KNOW SEARCH METHODOLOGY – INTEGRATIVE TREATMENT IN THORACIC CANCERS

    The search strategies were developed and tested through an iterative process by an experienced medical information specialist in consultation with the review team. The project was broken down into multiple topics and the searches performed in a staged fashion: Vitamin D (February 7, 2015), Complementary and Alternative Medicine (February 23), Natural Health Products (June 22), Mind/Body (June 26), and Diet/Nutrition (July 10).

    Using the OVID platform, we searched Ovid MEDLINE®, Ovid MEDLINE® In-Process & Other Non-Indexed Citations, Embase, and Allied and Complementary Medicine (AMED). We also searched the Cochrane Library on Wiley (including the Cochrane Database of Systematic Reviews, DARE, CENTRAL and HTA databases).

    Strategies utilized a combination of controlled vocabulary (e.g., “Neoplasms”, “Surgical Procedures, Operative”, “Vitamin D”) and keywords (e.g., cancer, surgery, cholecalciferol). Vocabulary and syntax were adjusted across the databases. With the exception of the Vitamin D search, results were limited to the publication years 2000 to the present. Human or unindexed records and opinion pieces were removed from the results of all searches where possible.

    The search will be updated on a scheduled basis and relevant citations incorporated.
  • Curcumin Methodology


    CURCUMIN RESEARCH QUESTION:
    What is the role of curcumin in the clinical management of cancer and survivorship?

    INCLUSION CRITERIA
    • English language article
    • Human
    • All tumor types/neoplastic cases [minimum of 25% study population with cancer]
    • KNOW beta topic -- contains data for all years
    • All outcomes including: Overall Survival (OS), Progression Free Survival (PFS), Quality of Life (QoL), and side effect management.
    • Females and males
    • All forms of curcumin preparations (including oral supplements, dietary, intravenous, injectable, topical)
    • Secondary prevention (articles that report data to prevent cancer from recurring)
    • Systematic Review articles and meta analyses with human data
    • Clinical guidelines

    EXCLUSION CRITERIA
    • Non- English language article
    • Non- human (eg. in vitro or in vivo non-human animal)
    • Non-neoplasms
    • Prevalence/usage of curcumin studies
    • Conference proceedings, trial postings without results; interim analyses

    KNOW SEARCH METHODOLOGY – CURCUMIN IN CANCER TREATMENT TRIALS

    The search strategy was developed and tested through an iterative process by an experienced medical information specialist in consultation with the review team. The database searches were executed on October 17, 2015. Using the OVID platform, we searched Ovid MEDLINE®, Ovid MEDLINE® In-Process & Other Non-Indexed Citations, Embase, and Allied and Complementary Medicine (AMED). We also searched the Cochrane Library on Wiley (including the Cochrane Database of Systematic Reviews, DARE, CENTRAL and HTA databases).

    Strategies utilized a combination of controlled vocabulary (e.g., “Curcumin”, “Curcuma “, “Neoplasms”) and keywords (e.g., turmeric, golden seal, cancer). Vocabulary and syntax were adjusted across databases. When possible, results were limited to human or unindexed records and opinion pieces were removed from the results.

    The search will be updated on a scheduled basis and relevant citations incorporated.

Phone & Fax:1-800-908-5175
Email: oncanp@gmail.com

The content on the KNOW website is not intended nor recommended as a substitute for medical advice, diagnosis, or treatment.
Always seek the advice of your own physician or other qualified health care professional regarding any medical questions or conditions.
The use of this website is governed by the KNOW Terms of Use

©2019 KNOW, Inc.

The Interactions Section is a feature that is being developed over the next year. In the meantime, here are two very helpful documents:

A Strategy for Controlling Potential Interactions Between Natural Health Products and Chemotherapy

  • Click to Enlarge



Dietary Supplements used concurrently with Conventional Treatment – A Methodology for Prevention of Interactions

  • Click to Enlarge

Phone & Fax:1-800-908-5175
Email: oncanp@gmail.com

The content on the KNOW website is not intended nor recommended as a substitute for medical advice, diagnosis, or treatment.
Always seek the advice of your own physician or other qualified health care professional regarding any medical questions or conditions.
The use of this website is governed by the KNOW Terms of Use

©2019 KNOW, Inc.